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Last updated on Aug 4, If you are between the ages of 18 an. Includes: how it works, upsides, downsides, bottom line, tips, response and effectiveness. Sildenafil is also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs). Sildenafil and Grapefruit. Grapefruit is known to potentially interact with many medications, including sildenafil. Do not take Viagra while also taking Revatio. Warnings. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Patients should be given clear instructions regarding the use of sildenafil. If you take sildenafil for pulmonary arterial hypertension, do not take Viagra® or other PDE5 inhibitors, such as tadalafil (Cialis®) or vardenafil (Levitra®). 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